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The first case of what was to become the Great Plague of London was
discovered in April 1665, in St Giles-in-the-Fields, a built-up area just to
the west of the walled City.
By the end of May, 11 people had been infected
enough to cause alarm. Victims were shut into their houses and the doors
were nailed shut and marked with a large red cross.
Nurses were hired to
take in food and carry out basic care, and guards were set on watch to make
sure that the sick (or their families) did not escape.

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